Clinical evidence supports caffeine, creatine, and sodium bicarbonate for improvement of multiple-sprint performance. Research tends to support β-alanine and bovine colostrum for team-sport performance, although further research is necessary to recommend these agents. Ribose, BCAAs, and HMB are not supported by the current evidence as supplements for team-sport performance. Typical supplemental regimens include 6 mg/kg for caffeine, 20 g/day for 5 to 7 days for creatine, and 0.2 to 0.3 g/kg 60 to 120 minutes before exercise for sodium bicarbonate. Limitations of these studies include a lack of evidence for women, adolescents, and children. In addition, there is a general lack of studies on team sport performance vs other activities (eg, cycling, running, weight training) in the sports nutrition/exercise physiology literature. Finally, the effects of multiple supplements and possible ingredients not listed on supplement packaging should be considered as well.